Epithelial-mesenchymal transition: The crossroads between differentiation, tumorigenicity, proliferation and DNA repair

About the speaker

Dr.Tulchinsky graduated from the Moscow State University and was awarded PhD in Molecular Biology at the Engelhardt Institute of Russian Academy of Sciences. He was as a Post-doctoral Fellow at the Danish Cancer Society Research Center before setting up his Laboratory in Leicester.

Dr.Tulchinsky’s interests are in the area of the interaction between EMT and other critical pathways leading to oncogenic transformation, cell proliferation, senescence or death. The data from his laboratory show that different EMT programs may cooperate with classical oncogenic pathways in oncogenic transformation. They may or may not affect cell cycle progression, senescence and DNA damage-induced apoptosis. Dr.Tulchinsky proposes that EMT programs determine such important cancer properties as altered sensitivity of disseminating cancers to different therapies or a phenomenon of dormant metastasis.